EVALUATION OF HYPOGLYCEMIC AND HYPOLIPIDEMIC ACTIVITIES OF METHANOLIC EXTRACT OF ANTIDESMA BUNIUS (LINN.) (FAMILY EUPHORBIACEAE) LEAF

Background and Objective: To evaluate hypoglycemic and hypolipidemic activities of methanolic extract of Antidesma bunius L. leaf. Methods: Diabetes was induced in male Long Evan rats by the administration of single intra-peritoneal injection of alloxan monohydrate (150 mg/kg b.w.). Effect of oral administration of two different doses of methanolic extract (250 and 500 mg/kg b.w.), metformin (100 mg/kg b.w.) alone for 7 days were examined on 0th, 3th, 5th and 7 th day of treatment to evaluate hypoglycemic and hypolipidemic activity. After 7 days of treatment, hypolipidemic effects were estimated by measuring serum biochemical parameters such as TC, TG, LDL and HDL. The survival rate, body weight and organ weight were also measured. Results: The leaves extract showed remarkable anti-diabetic property which was evaluated by the percentage of inhibition of the blood glucose level along with TG, TC, LDL and increase in HDL in high concentration of the plant extract compared to the metformin, a reference drug. Conclusion: It can be concluded that methanolic extract of A. bunius leaves possesses good hypoglycemic, hypolipidemic activity.