EFFECT OF NANOPATICLES ON PHARMACOKINETIC AND PHARMACODYNAMIC PROPERTIES OF ANTIMALARIAL AGENTS

Nanoparticles play an important role in a wide variety of fields including advanced materials, pharmaceuticals, and environmental detection and monitoring. They have been used in vivo to protect the drug entity in the systemic circulation, restrict access of the drug to the chosen sites and to deliver the drug at a controlled and sustained rate to the site of action. Many therapeutic agents have not been successful because of their limited ability to reach to the target site. There are various aspects of nanoparticle formulation, characterization, effect of their characteristics and their applications in delivery of drug molecules and can be exploited to achieve maximum potential of therapeutic agent . In present study designing nanoparticles , as a delivery system are to control particle size, surface properties and release of pharmacologically active agents in order to achieve the site-specific action of the drug at the therapeutically optimal rate and dose regimen against Plasmodium in mice model. Extracts of Azadirachta indica, Cinchona officinalis and Artemisia annua having anti plasmodium activities and chloroquine, mefloquine, artesunate synthetic drugs were selected in the study. Results obtained signifies the ability of nanoparticle to entrap hydrophilic and hydrophobic drugs with concomitant reduction in their toxicity potential, their versatility and their amenability for surface modification are the major factors responsible for their popularity in drug delivery research.