A study on role of lipid peroxidation in diabetic patients in Thiruvarur District

Introduction: Insulin affects many sites of mammalian lipid metabolism. It stimulates synthesis of fatty acid in liver adipose tissue and in the intestine. The insulin has also been reported to increase the cholesterol synthesis. The activity of lipoprotein lipase in white adipose is also increased. From this point of view, the assessment of various lipid fractions and lipid peroxide in the cases of Diabetes Mellitus may be of some help in the prognosis of patients and in preventing the possibilities of complications or secondary disorders. Aim of the study: To study the level of lipid peroxide in IDDM and NIDDM. To find out the correlation between Lipid peroxide and Lipid profile in both types of diabetes mellitus Materials and methods: Participants of the study group were selected from the outpatient's population of the Department of Medicine, Government Thiruvarur Medical College, Thiruvarur. 100 patients were selected for this study. Out of which 50 patients belong to NIDDM and 50 to IDDM group. 50 persons served as a healthy control. Results: There was a very good positive correlation between MDA and Cholesterol, TGL, LDL, VLDL in both NIDDM and IDDM cases. There was a negative correlation between MDA and HDL in NIDDM and IDDM cases. Conclusion: In the diabetes mellitus abnormally increased levels of lipid, lipoprotein and lipid peroxides in plasma may be due to the abnormal lipid metabolism. The maximum increase in lipid peroxide was found in a group of diabetes mellitus with complication. Elevated levels of lipid peroxide in diabetes mellitus may be due to the alteration of function of erythrocytes membrane. This inhibits the activity of superoxide dismutase enzyme leading to accumulation of superoxide radicals which cause the maximum lipid peroxidation and tissue damage in diabetes.