IN SILICO DOCKING STUDIES, SYNTHESIS AND CHACTERIZATION OF SOME NOVEL 1,3,4 THIADIAZOLE ANALOGUES OF 4-AMINO HIPPURIC ACID AS POTENT ANTIMICROBIAL AGENTS
Journal: Indian Drugs (Vol.55, No. 12)Publication Date: 2018-12-28
Authors : Daniel K.; Daniel V;
Page : 7-17
Keywords : ;
Abstract
The chemistry of heterocyclic compounds has been an interesting field of study for a long time. The heterocyclic nucleus 1,3,4-thiadiazole constitutes an important class of compounds for new drug development. The synthesis of novel thiadiazole derivatives and investigation of their chemical and biological behaviour have gained more importance in recent decades. Molecular docking is a key tool in structural molecular biology and CADD. The goal of the ligand protein is to predict the predominant binding model(s) of ligand with a protein of known 3D structure. In the present work, the motto was to develop new the anti-microbial agents. 1,3,4 Thiadiazole derivative of 4-amino hippuric acid show good anti-microbial activity and greater selectivity with glucosamine - 6 - phosphate synthetase (PDB ID in 2VF5) with flexible molecular docking studies.
Other Latest Articles
- OPEN INNOVATION IN INDIAN PHARMA
- Examining the Correlation between Acute Behavioral Manifestations of Concussion and the Underlying Pathophysiology of Chronic Traumatic Encephalopathy: A Pilot Study
- The Role of Celecoxib in Treatment of Psychiatric Disorders: A Review Article
- Portomesentric Vein Thrombosis: Our Experience of 3527 Laparoscopic Bariatric Surgery Procedures in Qatar
- Evaluation of Sibling-Ship Analysis in Secluded Lebanese Villages with Increased Mating Patterns
Last modified: 2019-01-02 19:24:36