MOTOR AND COGNITIVE DISORDERS IN DYNAMICS OF PARKINSON’S SYNDROME TREATMENT

The aim of the study was to improve the assessment of the dynamics of motor and cognitive deficits in patients with Parkinson's syndrome within 6 months on a background of an optimal antiparkinsonian therapy. We employed such methods as clinical neurological examination with a quantitative assessment of motor, cognitive, affective and psychotic disorders; analysis of medical records, and statistical analysis. The optimal antiparkinsonian therapy showed variation in the rate of disease progression, while about a quarter of the patients manifested rapid rate of progression of motor disorders. The deterioration of cognitive function was observed in 25 % of patients and in 12 % of patients with mild cognitive impairment during 6 months of developing dementia. Neurodynamic, regulatory and visual-spatial cognitive functions were affected most by negative dynamic in patients with Parkinson's syndrome. The antiparkinsonian therapy in 29.4 % of patients provoked psychotic violations, more often in patients with more severe visual-spatial and regulatory cognitive disabilities. We recommend using the test that had been involved in our work in order to improve the assessment of the dynamics in patients with Parkinson's syndrome. The highest rate of progression of motor function was marked in patients with mild cognitive impairment due to the relationship between cognitive and mental disorders. The qualitative feature of patients with severe cognitive impairment was predominant growth of motor disorders in axial sections.