Constitutive Developmental Modeling of Genomic Integrityand Epigenetic Interactivity in Neuroblastoma

The essential formulas of possible progression or non-progression are dimensionally and potentially highly divergent systems of operative aggressive growth and spread of a neuroblastoma. As such, an essential integrity of a given genomic profile and the interactivities of epigenetic factors reconstitute in clinical and pathologic terms the emergence of tumor evolution that proposes highly divergent profiles for possible resolution of the lesion, but also as biologic substrate for developmental emergence of malignant change and of progression of tumor growth and spread. The performance profile is historic characterization of a neoplasm that may regress completely in terms of such interaction between integral genome and epigenetic modeling of dimensional nature. The projected attributes of a neuroblastoma lesion is perforce dimensional reconstitution of such developmental dynamics as best characterized by systems of parametrically driven reconstitution of the genome of the neoplastic cells.