SYNTHESIS OF ACETYLENE EPOXYKETONE OF ALIFATIC SERIES
Journal: Azerbaijan Chemical Journal (Vol.0, No. 2)Publication Date: 2018-06-25
Authors : N.X.Husiyev E.S.Cafarova N.A.Aliyeva;
Page : 44-46
Keywords : epoxyketones; bromination; dehydrobromination; diastereoisomers; triethylamine;
Abstract
It has been established that an addition of bromine to 2-methyl-1,2-epoxy-4-hexen-3-ones leads to the mixture of two diastereoisomers of dibromoepoxyketones. In influence on mixture of diastereoisomers of 4,5-dibrom-2-methyl-1,2-epoxy-3-hexanes of equimolar quantity of triethylamine in acetone it takes place their partial dehydrobromination with formation of Е- and Z-isomers of 4,5-4-brom-2-methyl-1,2-epoxy-4-hexen-3-on. In a case of increase of reaction time of dibromoepoxyketones with excess of triethylamine in acetone it takes place the dehydrobromination with formation of 2-methyl-1,2-epoxy-4-hexyn-3-one
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