SYNTHESIS OF NANOSTRUCTURES ON THE BASIS OF DIAZACROWN ETHER AND MAGNETITE NANOPARTICLES LOADED BY CEPHALOSPORIN ANTIBIOTICS

1Baku State University 2SRI Geotechnological problems of oil, gas and Chemistry vazirova.leyla@gmail.com Received 05.02.2018 Synthesis of hydroxyl containing azacrown macrocycles (MC) that is able to mimic the properties of natural siderophores has been perfomed. On the basis of synthesized MC the supramolecular ensembles with magnetite nanoparticles, loaded by cephalosporin antibiotics were prepared. The synthesized MC was investigated by NMR, mass-, FTIR spectroscopy methods. The morphology of prepared nanoensembles was analyzed by scanning electron microscopy SEM, FTIR, X-ray diffraction XRD analysis methods. The quantitative analysis of nanostructures was made by atom absorbance spectroscopy (AAS) as well as on the basis of Lambert–Beer law by UV spectroscopy method. Prepared nanostructures were tested on gramnegative Escherichia Coli and gram -positive Staphylococcus aureus, having multi drug resistance propertie it has been found that the nanostructures significantly increase the antimicrobial effect of cephalsporins and decrease their minimum inhibitory concentration (MIC)