To Find out the Essentiality of Rv0526 Gene in Virulence of Mycobacterium tuberculosis by using In silico Approaches

Tuberculosis has emerged as a major world health problem, with almost one-third of the world population today infected with Mycobacterium tuberculosis H37Rv (M. tuberculosis). This gram-positive bacterium makes so many complications in its eradication completely. We need a proper way to inhibit its pathogenesis. Rv0526 (651bp/ 216 aa) is predicted to be a thioredoxin (Trx) like protein of Rv3673 family form a single transmembrane helix and show similarity to other M. tuberculosis thioredoxin-like proteins Rv1470, Rv1471, Rv1677. Trx are proteins that act as antioxidants by facilitating the reduction of other proteins by cysteine thiol-disulfide exchange, and it acts by its specifi c motif Cys37-Cys40 (CXXC). By using several bioinformatics tools, we may predict that Rv0526 may be an important component of cytochrome c maturation complex and show interaction with different other proteins. After knowing such specifi c features of this gene we may predict that mutational studies in Rv0526 gene may open new way towards the drug development.