IMMUNOHISTOCHEMICAL RISK ASSESSMENT OF THE LYMPHOGENOUS METASTASIS OF PAPILLARY THYROID CARCINOMA

Background. Metastatic papillary thyroid carcinoma to the cervical lymph nodes is a risk factor for disease recurrence. Immune cell infiltration in and around the tumor plays an important role in the processes of tumor progression and metastasis. Objective. Тo assess the nature of the immune cell infiltration in papillary thyroid cancer with lymphogenous metastases. Material and methods. An immunohistochemical study was performed on serial paraffin sections using monoclonal antibodies to CD3, CD4, CD1α, CD23, CD25, CD8 and TGF-β antigens. Conclusions. It was noted that in a CD1α positivity of 2.215 with a sensitivity of 60% and a specificity of 100%, as well as in a CD1α / CD3 level of 0.20 with a sensitivity of 100% and a specificity of 71.4%, lymphogenous metastases of papillary thyroid carcinoma can be predicted in women under 45 years of age. In cases when CD1α expression and CD1α / CD3 positivity in papillary thyroid carcinoma are above or below the threshold values, a discriminant equation may be used to diagnose lymphogenous metastases in women under 45 years of age.