JAK inhibitors: a promising direction for treating Rheumatoid Arthritis

Rheumatoid Arthritis (RA) is a chronic auto inflammatory disease that causes incapacitating changes both the musculoskeletal system and the internal organs [1]. Tumor Necrosis Factor inhibitors (TNFi) promised a new revolutionary era in RA approximately 20 years ago. Since then, different TNFi molecules appeared in that direction. Nowadays, clinicians have also added in their armamentarium the first bio similar in order to combat RA. The main question is: do they have achieved their goal regarding their efficacy, and if yes, at what extent?