THE IMPACT OF MORPHOFUNCTIONAL ABNORMALITIES IN THE LIVER WITH EXOTOXICITY CADMIUM ON THE FORMATION OF EXOSOMES IN HEPATOCYTES

Cadmium salts, getting into the body, affect the liver, changing the activity of many enzymes. Chronic cadmium poisoning reduces the activity of the antioxidant system, leads to the formation of free radicals and increased lipid peroxidation, disrupting cellular metabolism. This contributes to the formation of liver cells in many microvesicles, including exosomes, which, getting into the blood, carry information about violations in the cells of other organs, as exosomes are responsible for intercellular communication. These questions are of great practical interest for the clinic, but still poorly understood, therefore we investigated the questions of formation of exosomes in hepatocytes experimentally, in conditions of chronic cadmium exotoxicity.