Synthesis and Characterization of Some New Hydrazones with Anti‐Urease Activities
Journal: Journal of Ongoing Chemical Research (Vol.3, No. 2)Publication Date: 2018-12-31
Authors : Yusuf Sıcak;
Page : 71-74
Keywords : Organic Synthesis; Urease Inhibition Activity; Hydrazone; Enzyme Inhibitors; Urea;
Abstract
Hydrazones were considered as significant substrates in the drug discovery process. Therefore, a series of some new 1-(4-(1-(2-(4-substitutedphenyl)hydrazono)ethyl)phenyl)-3-(4-nitrophenyl)urea derivatives (2-8) were synthesized as potential urease inhibitory agents. The synthesized compounds were characterized by FTIR, ¹H NMR, 13C NMR, and elemental analysis (C, H, N). All compounds were evaluated in vitro for urease inhibitory potential. Among synthesized compounds, 8, 7, 6, and 4 showed excellent activities (IC50) i.e. 10.13±0.40, 12.15±0.22, 17.81±0.36, and 22.95±0.47 µM, respectively. This study has culminated in the identification of some compounds which can serve as leads for new potent urease inhibitors.
Other Latest Articles
- Antimicrobial and Urease Inhibition Activity of Volatile Oil Obtained from Aerial Parts of Thyme (Thymus vulgaris L.)
- COMPONENTS AND ANTIMICROBIAL ACTIVITY OF ESSENTIAL OIL OF AERIAL PARTS OF SAGE (Salvia officinalis L.)
- The chemical composition of Centaurea furfuracea Coss. & Dur. essential oil with antioxidant, anticholinesterase and antibiofilm activities
- A MINI REVIEW ON THE INDIGO DERIVATIVES
- Le Roman Historique contemporain face à « la scotticité »
Last modified: 2019-01-14 17:22:16