ANTIOXIDANT ACTIVITY OF THE EXTRACTS OF PLANTS OF THE FLORA OF THE NORTH CAUCASUS

Background: A significant increase the number of diseases associated with the development of oxidative stress dictates the need to find effective and safe agents with antioxidant activity. High efficiency and safety combine means of plant origin, which makes them promising objects for studying antioxidant properties. Thus, the aim of the study was to evaluate the antioxidant activity of plant extracts by in vitro tests. Materials and methods: The antioxidant properties of 9 plant extracts in the concentration range of 62.5-1000 μg / ml, obtained from: Cucurbita pepo L., Juglans nigra L., Tagetes patula L., Rudbeckia laciniataL., Grossularia reclinata (L.) Mill.,Ribes nigrum L., Rubus caesius L., Lysimachia punctata L., Morus alba L. was studied. Model systems of free radical generation included of DPPH-radical, superoxide, hydroxyl and nitrosyl radicals. Additionally, the chelating properties of the test extracts were studied. The results were processed statistically with the calculation of the IC50. Results: From 9 test extracts 3 have pronounced antioxidant properties - extracts of mulberry, pumpkin and walnut. In model systems, these objects interfered with the generation of DPPH radical, superoxide, hydroxyl and nitrosyl radicals, and also exhibited chelating activity, which was comparable to that of referents. Conclusion: The study showed the prospects of further study of extracts of mulberry, pumpkin and walnut as a means with antioxidant properties, and also demonstrated the possibility of using these objects to correct oxidative stress.