Microwave Irradiated and Conventional Synthesis, Antibacterial Activity Evaluation Studies of Tryptamine-Azole-Fluoroquinolone Conjugates
Journal: Archive of Biomedical Science and Engineering (Vol.4, No. 1)Publication Date: 2018-12-31
Authors : Yıldız Uygun Cebeci Serap Basoglu Özdemir Ahmet Demirbas Neslihan Demirbas; Sengül Alpay Karaoglu;
Page : 010-020
Keywords : Tryptamine; Hybrid compound; Multicom- ponent; Microwave; Antibacterial activity;
Abstract
Tryptamine was converted to the corresponding 1,2,4-triazole, 1,3,4-oxadiazole, 5-oxo-1,3-thia(oxa)zolidine and 5-(4-chlorophenyl)-1,3-thia(oxa)zole derivatives via several steps. 1,3,4-oxadiazole and 1,2,4-triazoles were then converted to the corresponding Mannich bases containing fluroquinolone core using a one-pot three-components procedure. Conventional and microwave-assisted methods were applied for all syntheses. All the newly synthesized compounds were screened for their antibacterial and most of them were found to have good–moderate antibacterial activity.
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