The Effects of Gene Polymorphisms in Interleukin-4 on the Susceptibility of Rheumatoid Arthritis in a Iraq Population

Rheumatoid Arthritis (RA) has been the most disease that recorded high number in Iraqi population, Interleukin-4 (IL-4) have been reported to associate with pathogenesis of rheumatoid arthritis (RA); which it is role of IL-4 genetic polymorphisms in RA. Method: A total of 50 unrelated IRAQ patients with RA and 40 healthy Iraqi volunteers with no family histories of any autoimmune diseases were recruited. The promoter IL-4-590 C/T polymorphisms were genotyped gene polymorphism implemented used RFLP technique. Result:The results show The genotype distributions and allele frequencies of IL-4-590 C/T polymorphisms in RA patients were significantly different from healthy Statistically significant differences were observed in genotypes for IL-4-590 .The frequencies of the T allele on the IL- 4-590 were significantly increased in RA patients. Conclusion. The IL-4-590 promoter polymorphisms may be associated with increased risk of RA and could be used as genetic marker for assessing the susceptibility and severity of RA in Iraqi.