Evaluation of Analgesic and Anti-diarrheal Activity of Ethanolic Extract of Swietenia mahagoni (Meliaceae) Leaves

Objective: The present study was aimed to investigate analgesic and anti-diarrheal activities of ethanolic extracts of Swietenia mahagoni leaves using experimental models. Methods: Analgesic activity of S. mahagoni leaves was tested by acetic acid-induced writhing test at a dose of 100 and 200 mg/kg and formalininduced hind paw-licking at 150 and 300 mg/kg administered orally where Indomethacin (10 mg/kg) was used as a standard analgesic drug. Anti-diarrheal activity was investigated using castor oil-induced diarrhea through oral administration of extracts at a dosage of 250 and 500 mg/kg. Loperamide (5 mg/kg) was used as a standard drug in this method. Results: In acetic acid-induced writhing test, ethanolic extract of S. mahagoni leaves showed maximum percentages of pain inhibition (56.14%) at 200 mg/kg dose in a dose-dependent manner where standard (Indomethacin) was 77.19%. The formalin-induced hind paw-licking test of S. mahagony leaves showed 43.08% inhibition in early phase where standard (Indomethacin) was 76.92% and in the late phase, 34.88% inhibition at 300 mg/kg dose where standard (Indomethacin) was 58.14%. In castor oil-induced anti-diarrheal test, ethanolic extract of S. mahagoni leaves showed 88.89% inhibition at 250 mg/kg and 94.45% inhibition at 500 mg/kg dose which was exactly the same of standard (Loperamide) inhibition. Conclusions: The current study indicates that ethanolic extract of S. mahagoni leaves have moderate analgesic and potential anti-diarrheal activity that support to the ethnopharmacological uses of this plant.