MESENCHYMAL CHONDROSARCOMA OF MANDIBLE -A RARE CASE STUDY AND LITERATURE REVIEW

A case report of 36 year old gentleman with no comorbids presented with swelling in left side of face for 2 months,Clinically,ulceroproliferative lesion of size 14 x 6 cm in left side of mandible and maxilla with marked facial asymmetry and left mandibular nerve paraesthesia.Computed Tomography of local part revealed large irregular heterodense mass obliterating oral aperture with bony destruction of mandible and ipsilateral maxilla, hard palate and softpalate submucosally. Histologically, tumour shows characteristic bimorphic appearance of small primitive appearing round cells with focal cartilaginous differentiation with immunohistochemical correlation suggestive of Mesenchymal Chondrosarcoma.Since lesion was inoperable,planned for Radiation therapy and single agent Doxorubicin.He developed grade IV neutropenia following first cycle of doxorubicin.Hence,further chemotherapy deferred.He received total dose 60 Gy of radiation.He presented a month later with paraplegia.MRI spine revealed an extradural mass compressing spinal cord at D2 vertebra.He received palliative radiation of 30 Gy.However,he succumbed to disease within a month.Mesenchymal chondrosarcoma is a rare tumour with aggressive course and rapid progression as seen in this case. Keyword