Synthesis, Characterization and Biological Screening of 10 Membered Tetraazamacrocyclic Cobalt Complex against Drug Resistant Bacterial Pathogens

Unsymmetrical macrocyclic CoII complex was synthesized by the template process using bis(benzil)ethylenediamine as precursor. Bis(benzil)ethylenediamine (L) reacts with cobalt(II) chloride and hydrazine HCl in a 1:1:1 molar ratio in methanol to give solid metal complex of the general composition [M(L)X2] (where, M = CoII, L = macrocyclic ligand and X = Cl ). The precursor and the metal complex of the macrocycle have been physico-chemically characterized by melting point, elemental analyses, molecular weight determinations, molar conductances, IR and electronic spectral studies. The synthesized complex was evaluated for in-vitro antibacterial activity against the multidrug resistant pathogens such as Staphylococcus aureus, Escherichia coli, Shigella Flexneri, Pseudomonas aeruginosa and Vibrio cholerae. The metal complex showed the significant antibacterial activity compared with commercial antibiotics. Further work can be extended through In-silico docking of these complexes and bacterial genome which can be given a better idea about genome metal interaction in molecular level.