A Clinical Comparative Study of Oral Aprepitant and Injection Palonosetronfor Prevention of Postoperative Nausea and Vomiting in Patients of Laparoscopic Cholecystectomy under General Anaesthesia

Aim:To assess and evaluate effect of oral aprepitant and injection palonosetronfor prevention of post-operative nausea vomiting [PONV] in patients posted for laparoscopic cholecystectomy under general anaesthesia. Background: Laparoscopic surgeries have been performed now a day's very frequently. The patients undergoing laparoscopic cholecystectomy under general anaesthesia have high risk for post-operative nausea and vomiting [PONV] with incidence up to 75%.Method:90 patients of ASA grade I and II undergoing laparoscopic cholecystectomy were registered for this study. They were divided randomly into 3groups of 30 each who received 1capsule (80 mg) aprepitant orally 3 hrs before and 2ml of normal saline IV 10 minute prior to induction in group A, or 1capsule (80 mg) aprepitant orally 3 hrs before and 2ml of normal saline IV 10 minute prior to induction in group P and placebo 1 capsule orally 3 hrs before and 2ml of normal saline intravenous (IV) 10 minute prior to induction in group C. After extubation patients were watched and monitored for nausea, retching and vomiting for 30 min.,60min, 2 hour, 6 hour, 12 hour, and 24 hour in postoperative period. Results: Palonosetron and Aprepitant both are the effective in reducing the incidence of post-operative nausea and vomiting up to 24 hours, when given prior to induction of general anaesthesia. Aprepitant is more effective than Palonosetron in reducing the nausea and vomiting in post-operative period.