CLINICAL AND MORPHOLOGICAL CHARACTERISTICS AND PROGNOSIS OF GLOMERULOPATHIES WITH EXTRACAPILLARY PROLIFERATION

Background. Glomerulopathies (GP) with extracapillary proliferation (EP) in glomeruli are the most severe forms, where clinical picture of the disease and the rate of decline in renal function depend on the degree of glomerular damage. The purpose of the study was to conduct a comparative clinical, morphological and prognostic analysis of GP forms accompanied by EP. Material and methods. The native kidney biopsies and clinical manifestations depending on the degree of EP were investigated using histological (light and luminescent microscopy), morphometric, and statistical methods. Results. The most severe clinical and morphological manifestations were observed in anti-GBM and pauci-immune glomerulonephritis (PIGN). In immunocomplex (IC) forms the crescents score was significantly lower, and the kidney function was more preserved. Conclusion. In PIGN the risk of renal failure development is increased and the chance of kidney function recovery is reduced as compared with IC forms of GP.