RESPONSE OF EXERCISE TRAINING ON HIGH DENSITY LIPOPROTEIN-CHOLESTEROL AND ITS SUBFRACTIONS

INTRODUCTION-Low level of HDL-C is an important independent risk factor for atherosclerotic cardiovascular disease. HDL-C levels can be modified by exercise training. This is because of various enzymes involved in HDL metabolism and the interaction of that with physical activity. Endothelial lipase is one such enzyme and the beneficial effect of exercise training on increasing the levels of HDL-C and its subfractions are linked to endothelial lipase enzyme involved in HDL metabolism. OBJECTIVES-The objective is to find out the response of exercise training on HDL cholesterol and its subfraction levels. METHODOLOGY- INTERVENTIONAL STUDY.60 apparently healthy subjects of 30-65 years of age newly enrolled in fitness centre were selected. Baseline assesment of fasting lipid profile and HDL subfractionation was done. Subjects underwent 24 weeks of supervised aerobic exercise training. After 24 weeks, fasting lipid profile and HDL subfractionation was repeated. RESULTS- By paired t test, statistically significant difference of total cholesterol, total HDL cholesterol , its subfraction and total cholesterol HDL ratio before and after exercise training was noted (p0.05). CONCLUSION- There was a beneficial effect of exercise training on High density lipoprotein cholesterol and its subfraction levels and was explined by endothelial lipase enzyme involved in HDL-C metabolism.