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N1,N1,N2,N2-Tetramethylethylenediaminium-N1,N2-disulfonic Acid Trifluoroacetate as Highly Effectual and Dual-Functional Catalyst for the Reaction of β-Ketoesters with Aryl Aldehydes and Urea/Thiourea

期刊名字: Chemical Methodologies (Vol.3, No. 4)

Publication Date:

论文作者 : ; ; ; ;

起始页码 : 509-518

关键字 : 3; 4-dihydropyrimidin-2-(1H)-one; 3; 4-dihydropyrimidin-2-(1H)-thione; Ionic liquid; Dual-functional catalyst N1; N1; N2; N2-Tetramethylethylenediaminium-N1; N2-disulfonic acid trifluoroacetate ([TMEDSA][TFA]2);

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论文摘要

In this research, the one-pot multi-component reaction of β-ketoesters with aryl aldehydes and urea/thiourea has been performed using a dual-functional ionic liquid-catalyst namely N1,N1,N2,N2-tetramethylethylenediaminium-N1,N2-disulfonic acid trifluoroacetate ([TMEDSA][TFA]2) in solvent-free conditions. By reason of dual-functionality of the catalyst (possessing acidic and basic sites), and also having two numbers of each site, it was highly effectual and general catalyst, and afforded the products {3,4-dihydropyrimidin-2-(1H)-ones and 3,4-dihydropyrimidin-2-(1H)-thiones} in short times with excellent yields. Moreover, a plausible mechanism based on dual-functionality of the catalyst has been proposed.

更新日期: 2019-03-21 05:07:18