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One-Pot synthesis of 2-amino-4H-chromenes using L-Prolineas a reusable catalyst

Journal: Journal of Medicinal and Chemical Sciences (Vol.2, No. 1)

Publication Date:

Authors : ;

Page : 35-37

Keywords : 2-amino-chromenes; Three-component reaction; L-proline; Reusable catalyst; Green solvent;

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Abstract

A new and efficient synthesis of2-amino-chromenes is achieved by one pot three-component reaction of aldehydes, malononitrile, and resorcinol using L-proline as a reusable catalyst.The key advantages of the present process are the use of a bioorganic and reusable catalyst, high yields of products, using green solvent and short reaction times from the principles of green chemistry point of view.

Last modified: 2019-03-21 05:28:36