Assessment of Serum Calcium, Magnesium and Cholecalciferol Status in the Patients of Migraine: A Cross Sectional Analytical Study

Background: Migraine which is a common intense headache occurs usually on one side of head accompained by the symptoms of nausea, vomiting and increased sensitivity to light and sound, photophobia and phonophobia. As the exact mechanisum in the pathogenesis of migraine is not clearly documented but it is thought that the deficiency of some important elements may have role to alleviate headache and migraine. Therefore we have evaluated the role of serum cholecalciferol, magnesium and calcium in the patients with migraine to confirm our results. Objective: The aim of this study is to evaluate the serum cholecalciferol, calcium and magnesium levels in the chronic migrainuers in comparison to normal healthy individuals. Methodology: A cross-sectional analytical study that was conducted at Isra University hospital and Liaquat University of health and medical sciences hospital, Hyderabad. Total sixty subjects were selected and divided into two groups as group-A comprising of 30 normal subjects and group-B consisting of 30 chronic migrainuers cases. The selection of case subjects were carried out through non-probability purposive sampling based on inclusion and exclusion criteria. Whole blood 5cc was taken from each subject and was immediately centrifuged at 3000 rpm for 10-15 minutes to separate out serum which is used for the quantification of cholecalciferol, calcium and magnesium levels in the serum. The data was analyzed on SPSS version 22.0. The continuous and categorical variables were analyzed using Student t-test and Chi square test. Results were described as statistically significant at p-values ≤ 0.05. Results: The data obtained by the present study showed that the mean±SD of age in group A and group B was 38.8±9.64 and 40.2±10.7 years respectively with p-value 0.49 in the normal and migraine patients. However, mean±SD of serum cholecalciferol was found to be 23.94±7.04 and 19.08±6.33ng/dl respectively with p-value 0.007. It has also been noticed that about 90% of the chronic migrainuers showed deficiency or insufficiency of serum cholecalciferol as compared to 73% in the control subjects. The mean±SD of serum calcium in both groups A and was noted as 9.28±0.67 and 8.89±0.83ng/dl respectively with p-value 0.047. In addition mean±SD of serum magnesium was found to be 1.88±0.24 and 1.75±0.20 ng/dl in both A and B groups respectively with p-value 0.022. Conclusion: It is concluded that serum cholecalciferol, calcium and magnesium was found to be in lower levels in the patients during migraine attack as compared to normal subjects having no complain of headache by the subjects.