Genetic Variants of Vitiligo

Vitiligo is a progressive skin disorder characterized by white and depigmented formations. The etiology is still unknown but genetic hypothesis a positive family history for vitiligo has been reported. Most important hypothesis is autoimmune hypothesis and neural hypothesis. Numerous additional HLA association studies have been published in Vitiligo. Genetic studies associated with vitiligo are not only related to the identification of genes that are susceptible to disease, but can also lead to the identification of genes associated with clinical aspects of the disease, the dynamics of the disease process or the time of manifestation of the first skin lesion. Continuous research on susceptibility genes is important to better understand the underlying mechanisms of vitiligo pathogenesis.