STUDY OF SERUM ADIPONECTIN, LEPTIN AND CHEMERIN LEVELS INPATIENTS WITH TYPE 2 DIABETES MELLITUS AND OBESITY

This cross sectional study was done in the Department of Biochemistry, K.P.C. Medical College, Jadvapur, Kolkata. A total of 200 male patients of more than 18 years were studied. 200 patients were divided into Case and Control group depending on presence of diabetes mellitus. Each group consist of 100 patients. In the present research, we showed that adiponectin was significantly higher in non diabetic control group with p< 0.001. In diabetic patients, adiponectin was suppose to be lower than normal. Statistically significant alliance was demonstrated in between Chemerin and Diabetes (p<0.001). Chemerin values were raised in diabetic individuals. Here, chemerin had statistically significant positive correlation with Cholesterol and triglycerides where p<0.001 & p=0.003 respectively. Similiarly, Lipoproteins like HDL, LDL and VLDL too had positive correlation with chemerin but of no statistical significance where p = 0.585, p= 0.253, p= 0.147 respectively. Glycemic parameters like FBS, PPBS and HbA1c were found to be positively correlated to chemerin with pronounced statistical significance (p<0.001 for each). Similar to Leptin, it was observed that chemerin too had positive correlation of statistical significance with HOMA -IR (p<0.001). This study concluded that there is a strong association of each of the parameters, namely serum adiponectin, leptin and chemerin with diabetes as well as obesity.