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A Journey Towards FeCl3 Catalysed Synthesis of Multisubstituted Pyrrole

Journal: Journal of Medicinal and Chemical Sciences (Vol.2, No. 3)

Publication Date:

Authors : ; ;

Page : 110-117

Keywords : Pyrrole; TosMIC; FeCl3; Cyclization; Lewis acid; Ethanol;

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Abstract

An efficient procedure was developed for the synthesis of different derivatives of 3,4-disubstituted pyrrole using TosMIC with ethyl cinnamate in DMF using lithium hydroxide monohydrate as a base. Further, trisubstituted pyrrole was synthesized using nitrostyrene, ethyl-propiolate and benzylamine in toluene as a reaction medium. This reaction was catalysed by lewis acid FeCl3. This strategy was further modified to synthesized tetra and penta substituted pyrrole using ethanol as a reaction medium keeping other conditions intact. This method is very economical and was successfully utilized for the synthesis of its derivatives with moderate to good yields.

Last modified: 2019-03-24 20:43:10