ASSESSMENT OF BAALC EXPRESSION LEVEL IN ACUTE MYELOID LEUKAEMIA PATIENTS AND ITS PROGNOSTIC SIGNIFICANCE

Baalc expression is an indicator of aggressiveness in aml. Overexpression of this gene is associated to poor of clinical outcome.highbaalc expression was independent associated with lower cr,shorterefs and shorter os. Aim of work:the study aimed to is assess baalc expression levels in acute myeloid leukaemia patients and then evaluate its prognostic significance. Subjects and methods:this study was conducted on 56 adult patients who were admitted to the clinical oncology unit including 35 males and 22 females.for all patients complete blood picture, ldh , bone marrow aspiration , immunophenotyping , cytogenetic analysis and assessment of baalc gene expression by real time pcr were done.results:the prognostic value for baalc gene expression was evaluated.the validity of baalc gene expression as a prognostic marker for aml showed that the sensitivity and specificity were 86.1% and 80% respectively. The relation between baalc gene expression and overall survival in aml patients revealed that patients with baalc ≥ 2.11 had shorter os than did those with lower level baalc.