Is STAT3 Signaling after Focal Ischemic Stroke Beneficial

Signal Transducer activator of transcription 3 (STAT3) is involved in cell signaling of neuronal stem cell proliferation, angiogenesis, and cell cycle progression. The jury is still out, about the effects of the STAT3 pathway activation after ischemia and if inhibiting or inducing this pathway leads to better functional recovery and neuronal stem cell proliferation to the penumbra. This review will better understand the role of STAT3 after focal ischemic stroke.