SKP1-Cullin1-F-Box Complex in Chronic InflammationAssociated Tumorigenesis
Journal: Open Access Journal of Cancer & Oncology (Vol.1, No. 2)Publication Date: 2017-08-05
Authors : Prateeti S; Chang SC;
Page : 1-3
Keywords : F-box; Ubiquitin-Proteasome system; Cancer Formation; Inflammation;
Abstract
In SKP1– cullin 1–F-box protein (SCF) E3 ligase complexes, F-box proteins are main subunits responsible for substraterecognition. F-boxes play vital roles in several cellular processes through ubiquitylation and consequent degradation of target proteins. Due to dysregulation of F-box protein-mediated proteolysis, it leads to many diseases. In this review, we give the important roles of F-box proteins and its family members in the regulation of many cellular activities.
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