SKP1-Cullin1-F-Box Complex in Chronic InflammationAssociated Tumorigenesis

In SKP1– cullin 1–F-box protein (SCF) E3 ligase complexes, F-box proteins are main subunits responsible for substraterecognition. F-boxes play vital roles in several cellular processes through ubiquitylation and consequent degradation of target proteins. Due to dysregulation of F-box protein-mediated proteolysis, it leads to many diseases. In this review, we give the important roles of F-box proteins and its family members in the regulation of many cellular activities.