Novel Docetaxel Formulation (NDLS) in Low Cardiac Reserve Ovarian Cancer

Ovarian cancer in patients with a history of breast carcinoma is not uncommon. We report here a case of successful management of a patient with ovarian cancer with omental tissue metastasis in a 40-year-old woman having poor ejection fraction with a prior history of breast cancer. The patient presented with enlarged ovaries with solid cystic masses suggestive of poorly differentiated metastatic carcinoma. In view of poor ejection fraction (heart failure) in the ovarian cancer patient, nanosomal docetaxel lipid suspension (NDLS, DoceAqualip) in combination with carboplatin was used in a neoadjuvant setting followed by surgical resection. This is the first such case report showing the successful treatment of carcinoma of ovary, with omental tissue metastasis, with DoceAqualip in a neoadjuvant setting followed by bilateral salpingo-oophorectomy in a patient having heart failure with a prior history of breast carcinoma.