Tumor Immune Infiltrate and Response to Chemotherapy

Chemotherapeutic agents are developed and used for their cytotoxic properties. Emerging evidence suggest that the efficacy of at least some of them is dependent on immune cells present within tumor and its microenvironment prior to chemotherapy as well as changes induced by chemotherapy. Type, number and density of immune cells are found to have prognostic and predictive value. Their evaluation can provide better prognostication compared to conventional methods.