IS EXISTENCE OF CLINICALLY SIGNIFICANT ANXIETY AND DEPRESSION A NEW RISK FACTOR FOR CHRONIC NON-INFECTIOUS DISEASES?

Aim. To assess the rate of anxiety/depression in population of the Ryazan region and its connection with chronic non-infectious diseases and their unfavorable outcomes within 36 months. Materials and Methods. The MERIDIAN research included 1622 individuals (1220 of urban and 402 of rural population) at the age of 25-64 years, of which 750 (42.6%) were men, 872 (53.8%) – women. Response to the study was 86.1%. Results. The rate of clinically significant anxiety/depression in the general sample was 62.0%, here, 5.2% felt a strong anxiety/depression, and 56.8% – a moderate one. In assessment of association of this risk factor with death from all reasons, no differences in the rate of anxiety were revealed in groups of living individuals and of those having died (61.9% and 70.8%, respectively, р=0,370). Multivariance analysis of proportionate risks Сох demonstrated no relationship between a risk factor and the end point (odds ratio, OR, 2.61, 95% confidence interval, CI, 0.98-5.54, р=0.09). The same results were obtained in assessment of relationship of this factor with a composite point (OR 0.61, 95% CI 0.26-1.07, р=0.105). According to data of univariable analysis, this risk factor was not associated with unfavorable outcomes. However, patients with clinically evident anxiety or depression taking any antidepressant or anxiolytic minimum for 14 days, had increased risk of death from all reasons (OR 6.12, 95% CI 1.83-20.52, р=0.003, Wald – 8.615) and a risk of development of a composite end point (OR 2.91, 95% CI 1.06-8.00, р=0.039, Wald – 4.266). Conclusion. The conducted study showed a high incidence of anxiety/depression among working population of the Ryazan region. No influence of this factor on the end points was found. Patients with a more severe depression or anxiety requiring a regular intake of medical drugs, had increased risk of death from all reasons and composite end point.