REACTION OF PERITONEUM AFTER INTRA-ABDOMINAL IMPLANTATION OF COMBINED HERNIOPROSTHESIS (EXPERIMENTAL STUDY)

Aim. To study the peculiarities of integration of a combined endoprosthesis made of biological and synthetic material with the tissues of the anterior abdominal wall of rats in intra-abdominal implantation. To compare the short-term results of intra-abdominal implantation of a combined endoprosthesis (CE) and a composite polyester mesh with single-sided adhesion (POC) in rats. Materials and Methods. The experiment was performed on 12 laboratory male rats of Vistar line. The animals were divided into two groups: the first group included six rats with implantation of a combined hernioprosthesis. The second group included six rats with implantation of a composite polyester mesh. The activity of adhesion process in the abdominal cavity was visually evaluated by the area of the formed adhesions, their type and strength according M.P. Diamond et al. (1992). Results. Immediate results and short-term complications of the performed operation were noted: in 33% of cases fistulas of the anterior abdominal wall were formed. Adhesion process in the abdominal cavity was most pronounced in animals with fistulas. In the course of study, a macroscopic evaluation of peculiarities of integration of endoprosthesis with the tissues of the anterior abdominal wall was performed, the best result was noted 6 months after the implantation. Conclusion. Zones of formation of adhesions were identified, which were the places of ligatures and the edges of the hernioprosthesis. In a comparative evaluation of the results of intraabdominal implantation of a combined endoprosthesis on the basis of a modified xenopericardium and of a composite mesh with one-sided adhesion by the methods of parametric statistics, comparable results were obtained. Formation of adhesion was most active at the edge of the endoprosthesis and at the sites of ligatures. In this connection, a more thorough treatment of the edges of the hernioprosthesis is required during implantation.