INVESTIGATION OF NEW DIHYDROPYRIDINE DERIVATIVE SOLUTIONS BY USING OF 2D DOSY NMR

As a result of the multicomponent condensation reaction between the thiophenyli¬dene¬malo¬no¬nitril and malononitriles with (S)-(–)-1-phenylethylamine new heterocyclic dihydropyridine derivative [(S)-(–)-6-amino-2-imino-1-(1-phenylethyl)-4-(thiophen-2-yl)-1,2-dihydropyridine-3,5-dicarbonitrile] was synthesized. DMSO-d6 solutions of the new compound have been investigated in the presence of β-cyclodextrin by using the 2D DOSY method. As confirmed by our investigations, water molecules formed the combined intermolecular hydrogen bond with the β-cyclodextrin and sample. Also, the hydrodynamic radius of new dihydropyridine derivative has been calculated