An Innovative New Treatment for Asherman Syndrome with an Intrauterine Amniograft: A Case Series

Objective: To determine if placing a cryopreserved amniotic membrane product (AmnioGraft) at the time of hysteroscopic treatment for Asherman syndrome will promote regeneration of the endometrium. Methods: This case-series evaluated the use of an allogenic AmnioGraft technology on women with the diagnosis of severe Asherman syndrome, a thin endometrial stripe, and a desire for future fertility. An AmnioGraft is a novel treatment modality to reduce infl ammation and adhesion formation after hysteroscopic adhesiolysis. The AmnioGraft is designed to prevent scaring, reduce infl ammation, and promote wound healing, which would be benefi cial in the treatment of Asherman syndrome. After obtaining consent, women underwent operative hysteroscopy, lysis of intrauterine synechiae under ultrasound guidance, and curettage. A 3.5x3.5cm AmnioGraft was wrapped around a Cook intrauterine balloon stent and inserted into the uterus for two weeks.