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A Pharmacokinetic Analysis and Pharmacogenomic Study of 6-mercaptopurine
Journal: International Journal of Pharmaceutical Sciences and Developmental Research (Vol.1, No. 1)Publication Date: 2015-08-31
Authors : Vicha A Katsila T Giannopoulou E Leontari H El Mubarak M Gravia A Chondrou V Symeonidis A Patrinos GP Kalofonos HP; Sivolapenko G;
Page : 002-007
Keywords : 6-Mercaptopurine; Pharmacokinetic analysis; Thiopurine S-methyl transferase;
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Abstract
Background: The efficacy and safety of 6-mercaptopurine (6-MP) therapy rely on the concentration of its metabolites. The aim of the current study is the pharmacokinetic analysis of 6-MP and the detection of its metabolites as well as the role of Thiopurine S-methyl transferase (TPMT), the enzyme associated with 6-MP metabolism, as a pharmacogenomics biomarker.
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Last modified: 2019-04-25 21:17:26