Adaptative Immunity, A True New Gene in Ophiocomina Nigra: An Ophuirid Igkappa Gene

It was shown 32 years ago that the sea star axial organ cells (AO cells) produced a spontaneous cytotoxicity against mouse cancerous cells. Recently, we discovered a sea star Ig kappa gene with immune properties. This gene was inserted in a CMV (cytomegalovirus) and finally in a plasmid called « young » plasmid. The induced« young » protein exerted a spontaneous cytotoxicity against Hela cells (cervix carcinoma cells) and at a weaker degree against dendritic celle, MSC cells.