Addenda and Appurtenant: Extra-Nodal NK/T Cell Lymphoma

An exceptional Non-Hodgkin's lymphoma in Asia or Mexico may be denominated as the extra-nodal natural killer (NK)/T cell lymphoma. As an aggressive tumour, it may gradually eradicate the anatomical structures of the head and neck, decimate the nasal cavity and emerge within the para-nasal sinuses. Nasal or extra-nasal natural killer (NK)/T cell lymphoma may be situated within the nasal cavity, nasopharynx, and upper gastrointestinal or aero-digestive tract. Nasal blockage or nasal discharge, systemic symptoms of rhinitis or sinusitis and an acute invasive fungal rhino-sinusitis in the immune compromised may be demonstrated. Extra-nodal NK/T cell lymphoma arises within the skin, gastrointestinal tract, testis, lung, eye, soft tissue and spleen. A diagnostic nasal endoscopy or a computerized tomography (CT) scan of the para-nasal sinuses may be mandated. Cellular morphology of atypical, enlarged lymphoid cells with abundant or clear cytoplasm, irregular nuclear borders, vesicular nuclei, granular chromatin and inconspicuous nucleoli admixed with an inflammatory infiltrate of histiocytes, neutrophils, immunoblasts and esoinophils may be enunciated. Immune markers of T cell differentiation such as a CD2+, CD3+, CD4+, CD5+, CD7+, CD8+, CD43+,CD45RO+ or CD45+, cy (cytoplasmic) CD3+ and a nonreactive surface CD3- may be delineated. An immune reactive Linker for Activation of T cells (LAT) with cytotoxic granule-associated proteins Granzyme B, Perforin and TIA 1 may be expounding.