Dynamics of Interleukin-2, Interleukin-6, Tumor Necrosis Factor Alpha Serum Levels and Interrelation of Cytokines in Patients with Liver Cirrhosis of Child- Pugh Classes A, B, C | Biomed Grid

The research objectives were to determine serum interleukins (IL-2, IL-6) and tumor necrosis factor alpha (TNF-α) and evaluate their interrelation in liver cirrhosis (class A, B, C according to Chad-Pugh). 117 patients were examined, and their cytokines levels were determined using enzyme-linked immunosorbent assay. Elevation of cytokine levels IL-2, IL-6 and TNF-α within reference values was found in liver cirrhosis cases, expect for level IL-6 in liver cirrhosis cases of class C. In these cases IL-6 level exceeds reference values and is within the limit of 9,94-25,21 pg/ml with average concentration of 14,89±4,96 pg/ml. Correlation is found between TNF-α and IL-6 (r =-0,499) in liver cirrhosis of class A and correlation between TNF-α and IL-2 (r = 0,421) is found in liver cirrhosis of class B