CONTRIBUTION OF VIOLATIONS OF NEUROMEDIATION IN THE BRAIN AND METABOLISM OF GLUCOSE IN THE LIVER AND MUSCLES OF RATS TO MECHANISMS OF FORMATION OF MORPHINE INTOXICATION

Background. The introduction of morphine to the body is followed by numerous metabolic violations. They are both shifts in the functioning of key neuromediator systems of the brain and visceral pathologies. Complex assessment of these violations will enable to create a complete idea of mechanisms of the formation of morphine intoxication with its subsequent metabolic correction. Purpose. Assessment of contribution of the central and peripheral metabolic violations to the formation of morphine intoxication. Material and methods. The complex research of components of the main neuromediator systems in various departments of the brain as well as indicators of glycolysis and a pentose phosphate pathway in the liver and muscles of rats in the main manifestations of morphine intoxication (acute, chronic) and a morphine withdrawal was conducted. Results. The signs of violation of catecholamine neuromediation in thalamic area and midbrain which manifest in three-four weeks after intoxication are revealed. In acute morphine intoxication the activation of glycolysis in the liver and skeletal muscles is noted. In chronic intoxication and withdrawal the effects of morphine manifest in the form of inhibited metabolism of glucose in the studied tissues. Conclusions. There are central and peripheral metabolic mechanisms of formation of morphine intoxication. The received data have important practical value and contribute significantly to understanding biological mechanisms of formation of this disease. These results can be theoretical justification for elaboration of methods of effective diagnostics and treatment of morphine addiction.