Safety monitoring of cytostatic handling
Journal: Journal of Pharmacy & Pharmacognosy Research (Vol.6, No. 6)Publication Date: 2018-11-01
Authors : Hilda M. Rodríguez Montero Elizabeth Reyes Reyes Tania M. Escalante Leyva Raidel Correa Aguila Antonio Torres Valle Elizabeth B. Cuétara-Lugo;
Page : 433-447
Keywords : cytostatic handling; Micronucleus test; occupational health;
Abstract
Context: The Institute of Oncology and Radiobiology (INOR) is the leading institution for the diagnosis, treatment and follow up of cancer in Cuba. Cancer treatment is mainly by three methods: surgery, radiotherapy and chemotherapy. Pharmacological treatments involve the use of dangerous substances such as cytostatics, the handling of which threat the health of the occupationally exposed staff. Aims: To evaluate a biomarker of genotoxicity indicative of DNA damage in the biomonitoring of occupational risks associated with the administration of antineoplastic drugs to hospitalized patients. Methods: The determination of the frequency of micronuclei, in cells of the exfoliated oral mucosa was determined (Micronucleus test) in subjects who administer cytostatic drugs at the institute and a control group formed by administrative personal. Results: Present results evidenced that all exposed subjects possess the same DNA damage that non-exposed-ones. Such results are in concordance with the proper use of primary protection barriers and the adhesion to normalized operational procedures. Conclusions: The frequency of micronuclei is a useful biomarker for assessing DNA damage associated with the administration of antineoplastic drugs. The risk perception analysis (RISKPERCEP) in occupationally exposed subjects complements the occupational safety monitoring.
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