CLINICAL AND BIOCHEMICAL EVALUATION OF THYMOQUINONE GEL IN THE TREATMENT OF CHRONIC PERIODONTITIS

Aim of study: toinvestigate the effect of Thymoquinone gel on the clinical periodontal parameters as well as the level of IL-1β and total anti-oxidant capacity levels in gingival crevicular fluid of chronic periodontitis patients. Patients and methods: This study was conducted on 68 subjects of both sexes with age ranged 25-58 years old. 48 patients were clinically diagnosed with moderate to severe chronic periodontitis. The 68 subjects were grouped into three groups; Group I (24 patients): received non-surgical periodontal therapy and Thymoquinone gel (0.1 % w/w), Group II (24 patients): received only non-surgical periodontal therapy and Group III: 20 healthy subjects (control group). The clinical parameters including plaque index (PI), gingival index (GI), probing depth (PD) and clinical attachment level (CAL) as well as the level of IL-1β and total anti-oxidant capacity levels in gingival crevicular fluid were recorded at baseline (prior to treatment) and at weeks 4 and 12 after treatment. Results: Groups I and II exhibited statistically significant differences in all clinical and biochemical parameters compared to baseline. Significant improvement in group I was detected at 4 weeks interval regarding biochemical parameters when compared to group II. Conclusion:non-surgical periodontal therapy improves all clinical and biochemical parameters in both groups significantly. Adjunctive use of thymoqinon gel improve the biochemical parameters significantly after 4 weeks only.