GLIOSARCOMA - A rare but aggressive tumour - Report of 2 cases

Gliosarcoma is a rare malignant tumour of central nervous system presenting in the middle age group population. It has a biphasic histopathologic pattern with neural mesenchymal elements. Prognosis is poor. Here we report two cases treated at our department.Case description - Both patients were diagnosed with histopathology from surgically excised specimen. Immunohistochemistry reporting was done for confirmation. They were prescribed 60Gy radiation with concurrent Temozolamide 100mg daily till completion of radiation. Post radiation films showed gliotic changes only. Adjuvant Temozolamide was continued for 3 cycles as 150 mgm2 body surface area for days 1-5 q28 days. Further chemotherapy was discontinued as there was worsening to Karnofsky performance scale 40. Follow up scans were suggestive of progression. Patients were then put on supportive care.Conclusion - Gliosarcoma is a rare, aggressive variant of GBM. In spite of definitive treatment measures, progression is certain with worsening of symptoms.