IN VITRO CELL GROWTH-INHIBITING AND IMMUNE MODULATING EFFECTS OF HEAT-SENSITIVE BIOACTIVE SUBSTANCES ISOLATED FROM PARASITE AND INFECTED HOST TISSUES AFTER EXPERIMENTAL TRICHINELLOSIS

Journal: TRADITION AND MODERNITY IN VETERINARY MEDICINE (Vol.4, No. 1)

Publication Date: 2019-02-01

Authors : Neli Tsocheva-Gaytandzhieva Svetlozara Petkova Elena Nikolova Reneta Toshkova Margarita Gabrashanska Ivelin Vladov Veselin Nanev Valeria Dilcheva;

Page : 39-45

Keywords : experimental trichinellosis; heat-sensitive bioactive substances; antiproliferative and immune modulating activities; lymphocytes; bone marrow cells; in vitro.;

Source : Download Find it from : Google Scholar

Abstract

Antiproliferative effects of biochemically isolated from Trichinella spiralis muscle larvae, livers and spleens from healthy and T. spiralis infected rats heat-sensitive bioactive substances (HSBSes) were studied in vitro on nonactivated and mitogen activated with phytohemagglutinin (PHA) lymphocytes and bone marrow precursor cells. Stronger antiproliferative effects were established for HSBSes from parasite and infected host tissues than from healthy rats. Stronger growth inhibiting and immune modulating activities of HSBSes were determined on PHA activated lymphocytes. Also antiproliferative effects were established on bone marrow precursor cells. This probably was a result of changed liver metabolism and immunity in T. spiralis infected hosts

Main Menu

Searching By

PARTNERS

IN VITRO CELL GROWTH-INHIBITING AND IMMUNE MODULATING EFFECTS OF HEAT-SENSITIVE BIOACTIVE SUBSTANCES ISOLATED FROM PARASITE AND INFECTED HOST TISSUES AFTER EXPERIMENTAL TRICHINELLOSIS

Abstract

Advertisement