Glycated Hemoglobin Level is Significantly Associated with The Severity of Ischemic Stroke in Libyan Non-Diabetic and Diabetic Patients| Biomed Grid

Background: Diabetes is metabolic disorder that lead to atherosclerosis which could lead to vascular accident like acute ischemic stroke. To formulate effective preventive measures, it's important to understand the impact of glycemic status on the severity of acute ischemic stroke in adult type II diabetic patient. Aim of study: Study to analyze the role of HbA1c level on the severity of acute ischemic stroke in adult over 39-year diabetic type II Libyan patients. Patients and methods: This is case control study of 40 subjects with acute ischemic stroke and diabetes type II (case subjects) were categorized in to 2 sub-groups based on HbA1c level at time of admission with acute ischemic stroke, patients with diabetes and acute ischemic stroke with good glycemic control (<7HbA1c) and patient with acute ischemic stroke and diabetes with poor glycemic control (>7HbA1c). 40 acute ischemic stroke patients without diabetes as controls, the diagnosis of cerebral infarction was confirmed by brain - CT scan. Neurological impairment was evaluated using the National Institutes of Health Stroke Scale (NIHSS). All subjects have blood hemoglobin A1c (HbA1c) measured at admission. Result: Poor glycemic control group had statistically significant high HbA1c value (8.510±1.260) when compared to good glycemic control group (5.921±0.501) and non-diabetic (5.8±0.540). Stroke severity at admission were higher in patients with poor glycemic control than in those with good glycemic control (90% vs 46.33%) with good glycemic control. Conclusion: Glycemic control has significant association on severity of ischemic stroke patients with diabetes. Estimation of HbA1c level at the time of admission might be predictor of the severity of neurological impairment in patient with acute ischemic stroke and diabetes mellitus type II