Chronic demyelinating polyneuropathy associated with anti-ganglioside GQ1b antibodies in peripheral T-cell lymphoma
Journal: Archives of Hematology Case Reports and Reviews (Vol.4, No. 1)Publication Date: 2019-02-07
Authors : Salem Bahashwan Carolyne Croizier Xavier Moisset Romain Guièze Bertrand Evrard Olivier Tournilhac Jacques-Olivier Bay; Richard Lemal;
Page : 008-010
Keywords : CIDP; Lymphoma; Anti-ganglioside;
Abstract
Malignant lymphoma can cause peripheral neuropathy through various mechanisms. We report the case of 67-year-old man with chronic motor and sensory axonal demyelinating polyneuropathy associated with anti-ganglioside GQ1b antibodies in serum and cerebrospinal fluid (CSF) as an initial presentation of peripheral T-cell lymphoma, not otherwise specified. The patient was treated with chemotherapy for T-cell lymphoma, and achieved complete remission. Motor function recovered completely and sensory function improved. Neurological improvement was concurrent with the disappearance of serum and CSF anti-ganglioside GQ1b antibodies. This is the first report of chronic demyelinating polyneuropathy associated with anti-ganglioside GQ1b antibodies in peripheral T-cell lymphoma.
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