Preimplantation Genetic Diagnosis for Human Leukocyte Antigen Matching: The Generation of the Savior Sibling and the “Gift of Life”

In vitro fertilization (IVF) in conjunction with preimplantation genetic diagnosis (PGD) for mutation detection and human leukocyte antigen (HLA) matching for hematopoietic stem cell transplantation (HSCT) is a unique technology of modern clinical embryology. The technology should be offered to any family with a condition that requires matched-related HSCT. Today, PGD-HLA matching is a realistic option for families in need of treating an affected sibling, when no HLA-matched donor is available. Offering the option of HSCT from a savior sibling immediately upon the diagnosis of the condition in the child of a family is crucial, since it shortens the time until the birth of the savior sibling through IVF-PGD and increases the probability of cure by HSCT. The success of the treatment can be achieved only through a multidisciplinary team work and the cure can be “gifted” to the sick child through the savior sibling.