A Review: Targeted Cancer Therapy as a Fight Against Brain Tumor| Biomed Grid

The brain tumor is the second most deadly disease for causing death among cancer patients. It can be treated by conventional treatment techniques i.e. chemotherapy, neurosurgery, and radiotherapy but with some improvement, it mostly results in the increase of medical problems by non-specific targeting of normal cells in addition to the cancerous cells. Different CNS diseases include cerebrovascular disease, Parkinson's disease, epilepsy, Alzheimer disease, and other neurogenerative disorders. Despite advance ongoing research, a number of patients are dying every year by these diseases. Different techniques are used including invasive and non- invasive to treat these diseases. Molecular targeting agents are being used which have the advantages of easily crossing multiple barriers i.e. Brain blood barrier (BBB), cerebrospinal fluid (CSF) and brain bloodtumor barrier to reach the malignant site, low toxicity and better efficacy than conventional treatment techniques. Antibodies, nanoparticles and proton therapy can be used for specific targeting of tumor antigens which spare normal cells from the diseased ones. Although there are some issues i.e. difficulty in crossing multiple barriers, toxicity profiles, sometimes non-specific delivery, degradation of therapeutic agents by the enzymes. Research work is in progress to solve these issues